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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase mTOR | ||
| Ligand | BDBM50092767 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1501613 (CHEMBL3587365) | ||
| IC50 | 300±n/a nM | ||
| Citation |  Mortensen, DS; Perrin-Ninkovic, SM; Shevlin, G; Zhao, J; Packard, G; Bahmanyar, S; Correa, M; Elsner, J; Harris, R; Lee, BG; Papa, P; Parnes, JS; Riggs, JR; Sapienza, J; Tehrani, L; Whitefield, B; Apuy, J; Bisonette, RR; Gamez, JC; Hickman, M; Khambatta, G; Leisten, J; Peng, SX; Richardson, SJ; Cathers, BE; Canan, SS; Moghaddam, MF; Raymon, HK; Worland, P; Narla, RK; Fultz, KE; Sankar, S Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. J Med Chem58:5323-33 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase mTOR | |||
| Name: | Serine/threonine-protein kinase mTOR | ||
| Synonyms: | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP12-rapamycin complex-associated protein | FRAP | FRAP 1 (mTOR) | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | Mammalian Target of Rapamycin (mTOR) | P42345 | RAFT1 | RAPT1 | Rapamycin and FKBP12 target 1 | Rapamycin target protein | Serine/threonine-protein kinase (mTOR) | mTORC2 | ||
| Type: | Rapamycin target protein | ||
| Mol. Mass.: | 288917.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P42345 | ||
| Residue: | 2549 | ||
| Sequence: |
| ||
| BDBM50092767 | |||
| n/a | |||
| Name | BDBM50092767 | ||
| Synonyms: | CHEMBL3586402 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H27N5O3 | ||
| Mol. Mass. | 397.4708 | ||
| SMILES | CO[C@H]1CC[C@H](CC1)N1CC(=O)Nc2ncc(nc12)-c1ccc(nc1)C(C)(C)O |r,wD:2.1,5.8,(-2.38,8.32,;-1.32,7.7,;-1.32,6.16,;-2.65,5.39,;-2.66,3.85,;-1.33,3.08,;.01,3.84,;.01,5.38,;-1.33,1.54,;-2.68,.77,;-2.68,-.77,;-3.75,-1.39,;-1.33,-1.54,;,-.77,;1.33,-1.54,;2.66,-.77,;2.66,.77,;1.33,1.54,;,.77,;4,1.54,;3.99,3.08,;5.33,3.85,;6.66,3.08,;6.66,1.54,;5.33,.77,;7.99,3.86,;9.06,3.24,;9.06,4.47,;7.99,5.09,)| | ||
| Structure | 
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