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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ephrin type-B receptor 4 | ||
| Ligand | BDBM50100327 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1454052 (CHEMBL3361798) | ||
| IC50 | 15±n/a nM | ||
| Citation |  Unzue, A; Dong, J; Lafleur, K; Zhao, H; Frugier, E; Caflisch, A; Nevado, C Pyrrolo[3,2-b]quinoxaline derivatives as types I1/2 and II Eph tyrosine kinase inhibitors: structure-based design, synthesis, and in vivo validation. J Med Chem57:6834-44 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ephrin type-B receptor 4 | |||
| Name: | Ephrin type-B receptor 4 | ||
| Synonyms: | EPHB4 | EPHB4_HUMAN | Ephrin receptor | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11 | VHL/Ephrin type-B receptor 4 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 108273.51 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P54760 | ||
| Residue: | 987 | ||
| Sequence: |
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| BDBM50100327 | |||
| n/a | |||
| Name | BDBM50100327 | ||
| Synonyms: | CHEMBL3321813 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H16F4N6O2 | ||
| Mol. Mass. | 508.4272 | ||
| SMILES | NC(=O)c1c(N)n(-c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2F)c2nc3ccccc3nc12 |(24.7,-37.03,;23.21,-37.43,;22.18,-36.28,;22.74,-38.89,;23.64,-40.14,;25.18,-40.14,;22.74,-41.38,;23.21,-42.85,;24.72,-43.17,;25.2,-44.63,;26.7,-44.95,;27.18,-46.42,;26.15,-47.56,;28.69,-46.74,;29.71,-45.6,;31.21,-45.91,;31.69,-47.38,;30.66,-48.53,;29.16,-48.21,;31.14,-49.99,;30.1,-51.13,;32.64,-50.31,;31.9,-51.32,;24.17,-45.78,;22.66,-45.46,;22.18,-43.99,;20.68,-43.67,;21.27,-40.91,;19.94,-41.68,;18.61,-40.91,;17.27,-41.68,;15.94,-40.91,;15.94,-39.37,;17.27,-38.6,;18.61,-39.37,;19.94,-38.6,;21.27,-39.37,)| | ||
| Structure | 
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