Reaction Details |
| Report a problem with these data |
Target | Melanin-concentrating hormone receptor 1 |
---|
Ligand | BDBM50120677 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1518193 (CHEMBL3619840) |
---|
Ki | 12±n/a nM |
---|
Citation | Devasthale, P; Wang, W; Mignone, J; Renduchintala, K; Radhakrishnan, S; Dhanapal, J; Selvaraj, J; Kuppusamy, R; Pelleymounter, MA; Longhi, D; Huang, N; Flynn, N; Azzara, AV; Rohrbach, K; Devenny, J; Rooney, S; Thomas, M; Glick, S; Godonis, H; Harvey, S; Cullen, MJ; Zhang, H; Caporuscio, C; Stetsko, P; Grubb, M; Huang, C; Zhang, L; Freeden, C; Murphy, BJ; Robl, JA; Washburn, WN Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies. Bioorg Med Chem Lett25:4412-8 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Melanin-concentrating hormone receptor 1 |
---|
Name: | Melanin-concentrating hormone receptor 1 |
Synonyms: | G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 39075.64 |
Organism: | RAT |
Description: | Melanin Concentrating Hormone 1 GPR24 RAT::P97639 |
Residue: | 353 |
Sequence: | MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
|
|
|
BDBM50120677 |
---|
n/a |
---|
Name | BDBM50120677 |
Synonyms: | CHEMBL3618341 |
Type | Small organic molecule |
Emp. Form. | C23H21ClN4O4 |
Mol. Mass. | 452.89 |
SMILES | COc1cc(ccc1OCC(O)C1CC1)-n1cnn2cc(cc2c1=O)-c1ccc(Cl)cn1 |
Structure |
|