| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM50125049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1518969 (CHEMBL3626121) |
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| IC50 | 530±n/a nM |
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| Citation |  Martin, RE; Aebi, JD; Hornsperger, B; Krebs, HJ; Kuhn, B; Kuglstatter, A; Alker, AM; Märki, HP; Müller, S; Burger, D; Ottaviani, G; Riboulet, W; Verry, P; Tan, X; Amrein, K; Mayweg, AV Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. J Med Chem58:8054-65 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone synthase | C11B2_MOUSE | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B2, mitochondrial | Cytochrome P450C11 | Steroid 11-beta-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57397.51 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109884 |
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| Residue: | 500 |
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| Sequence: | MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQG
QENLHLEMHQVFRELGPIFRHSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHR
ELRGLRRGVFLLNGPEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNA
RGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLSPGSLKFIHALHSMFKSTSQLLFL
PKSLTRWTSTRVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAELISQGSLP
LDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQKALRQESLAAEASIAANPQKAMS
DLPLLRAALKETLRLYPVGGFLERILSSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRP
ERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVETLRQEDVQM
AYRFVLMPSSSPVLTFRPVS
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| BDBM50125049 |
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| n/a |
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| Name | BDBM50125049 |
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| Synonyms: | CHEMBL3623830 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N3O |
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| Mol. Mass. | 305.3737 |
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| SMILES | CCC(=O)N[C@@H]1CCCc2c1cncc2-c1ccc(cc1)C#N |r| |
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| Structure | 
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