Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50154368 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1560509 (CHEMBL3776781) |
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IC50 | 16380±n/a nM |
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Citation | Lotesta, SD; Marcus, AP; Zheng, Y; Leftheris, K; Noto, PB; Meng, S; Kandpal, G; Chen, G; Zhou, J; McKeever, B; Bukhtiyarov, Y; Zhao, Y; Lala, DS; Singh, SB; McGeehan, GM Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists. Bioorg Med Chem24:1384-91 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50154368 |
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n/a |
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Name | BDBM50154368 |
Synonyms: | CHEMBL3775476 |
Type | Small organic molecule |
Emp. Form. | C22H17FN2O3 |
Mol. Mass. | 376.3804 |
SMILES | Fc1ccc2N(Cc3ccc4OCC(=O)Nc4c3)c3ccccc3COc2c1 |
Structure |
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