| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50175063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580268 (CHEMBL3811934) |
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| IC50 | 390±n/a nM |
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| Citation |  Ontoria, JM; Paonessa, G; Ponzi, S; Ferrigno, F; Nizi, E; Biancofiore, I; Malancona, S; Graziani, R; Roberts, D; Willis, P; Bresciani, A; Gennari, N; Cecchetti, O; Monteagudo, E; Orsale, MV; Veneziano, M; Di Marco, A; Cellucci, A; Laufer, R; Altamura, S; Summa, V; Harper, S Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs. ACS Med Chem Lett7:454-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50175063 |
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| n/a |
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| Name | BDBM50175063 |
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| Synonyms: | CHEMBL3808977 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N6O3S |
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| Mol. Mass. | 492.593 |
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| SMILES | CNC(=O)CCCCC[C@H](NC(=O)c1cncs1)c1ncc([nH]1)-c1ccc2cc(OC)ncc2c1 |r| |
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| Structure | 
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