Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase 7 |
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Ligand | BDBM50187114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1587896 (CHEMBL3826557) |
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IC50 | 8.0±n/a nM |
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Citation | Muraoka, T; Ide, M; Morikami, K; Irie, M; Nakamura, M; Miura, T; Kamikawa, T; Nishihara, M; Kashiwagi, H Discovery of a potent and highly selective transforming growth factorß receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD). Bioorg Med Chem24:4206-4217 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase 7 |
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Name: | Mitogen-activated protein kinase kinase kinase 7 |
Synonyms: | M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1) |
Type: | Protein |
Mol. Mass.: | 67199.89 |
Organism: | Homo sapiens (Human) |
Description: | O43318 |
Residue: | 606 |
Sequence: | MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS
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BDBM50187114 |
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n/a |
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Name | BDBM50187114 |
Synonyms: | CHEMBL3823303 |
Type | Small organic molecule |
Emp. Form. | C25H28FN7O2 |
Mol. Mass. | 477.5339 |
SMILES | CCc1cc(Nc2ncc(F)c(n2)-c2cnc3cccnn23)cc(OCCN2CCC(O)CC2)c1 |
Structure |
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