BindingDB PrimarySearch

Found 11925 hits with Last Name = 'ide' and Initial = 'm'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Isoform 1 of Calcitonin receptor (1) (Homo sapiens (Human))	BDBM50110268 (CHEMBL2369895 \| CSNLSTCVLGKLSQELc[DKLQK]YPRTNTGSGT...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	0.0230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells				J Med Chem 45: 1108-21 (2002) BindingDB Entry DOI: 10.7270/Q2N015V5
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
Isoform 1 of Calcitonin receptor (1) (Homo sapiens (Human))	BDBM50024170 (CHEMBL2369912) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells				J Med Chem 45: 1108-21 (2002) BindingDB Entry DOI: 10.7270/Q2N015V5
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
Isoform 1 of Calcitonin receptor (1) (Homo sapiens (Human))	BDBM50110272 (CHEMBL2369907 \| CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGT...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	0.0510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells				J Med Chem 45: 1108-21 (2002) BindingDB Entry DOI: 10.7270/Q2N015V5
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527524 (CHEMBL4566742) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	0.0617	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Isoform 1 of Calcitonin receptor (1) (Homo sapiens (Human))	BDBM50110265 (CHEMBL2369886 \| CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGT...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	0.0690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells				J Med Chem 45: 1108-21 (2002) BindingDB Entry DOI: 10.7270/Q2N015V5
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
Isoform 1 of Calcitonin receptor (1) (Homo sapiens (Human))	BDBM50110275 (CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide \| CHEMBL2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	0.0690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells				J Med Chem 45: 1108-21 (2002) BindingDB Entry DOI: 10.7270/Q2N015V5
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527552 (CHEMBL4435111) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527532 (CHEMBL4441748) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	0.123	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527537 (CHEMBL4453005) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.155	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527531 (CHEMBL4524402) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	0.155	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 2C (Rattus norvegicus (Rat))	BDBM50115642 ((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...) Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Center for Pharmacy Curated by ChEMBL					Assay Description The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine				J Med Chem 45: 3280-5 (2002) BindingDB Entry DOI: 10.7270/Q28051ZZ
University Center for Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527528 (CHEMBL4441871) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.162	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527550 (CHEMBL4461456) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50068071 (CHEMBL2370908 \| SRIF) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeast Louisiana University Curated by ChEMBL					Assay Description In vitro binding affinity at somatostatin 2 receptor in transfected HEK 293 cell using [125 I]Tyr11-SRIF-14 as radioligand				J Med Chem 41: 4693-705 (1998) Article DOI: 10.1021/jm980118e BindingDB Entry DOI: 10.7270/Q2TT4RNG
Northeast Louisiana University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Rattus norvegicus (Rat))	BDBM50115643 ((+/-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro...) Show SMILES COc1cccc2Cc3ccccc3C3CN(C)CCN3c12 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Center for Pharmacy Curated by ChEMBL					Assay Description The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine				J Med Chem 45: 3280-5 (2002) BindingDB Entry DOI: 10.7270/Q28051ZZ
University Center for Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527535 (CHEMBL4589927) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.224	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527533 (CHEMBL4592553) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.234	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM50235631 (CHEMBL4060827) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay				Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM50235630 (CHEMBL4093096) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay				Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50068063 ((12S,15R,18S)-9-(4-Amino-butyl)-3-benzyl-15-(4-hyd...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeast Louisiana University Curated by ChEMBL					Assay Description In vitro binding affinity at somatostatin 2 receptor in transfected HEK 293 cell using [125 I]Tyr11-SRIF-14 as radioligand				J Med Chem 41: 4693-705 (1998) Article DOI: 10.1021/jm980118e BindingDB Entry DOI: 10.7270/Q2TT4RNG
Northeast Louisiana University Curated by ChEMBL					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM50272772 (10-(4-Amino-butyl)-19-(2-amino-3-phenyl-propionyla...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeast Louisiana University Curated by ChEMBL					Assay Description In vitro binding affinity at somatostatin 2 receptor in transfected HEK 293 cell using [125 I]Tyr11-SRIF-14 as radioligand				J Med Chem 41: 4693-705 (1998) Article DOI: 10.1021/jm980118e BindingDB Entry DOI: 10.7270/Q2TT4RNG
Northeast Louisiana University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527555 (CHEMBL4530777) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	0.302	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527560 (CHEMBL4444578) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.316	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527567 (CHEMBL4473426) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.316	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527554 (CHEMBL4460623) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	0.355	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin D2 receptor 2 (Mus musculus (mouse))	BDBM50356677 (CHEMBL1917592) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Serono S.A. Curated by ChEMBL					Assay Description Displacement of [3H]PGD2 from mouse CRTH2 expressed in human HEK cells by liquid scintillation counting				J Med Chem 54: 7299-317 (2011) Article DOI: 10.1021/jm200866y BindingDB Entry DOI: 10.7270/Q2N58MS1
Merck Serono S.A. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527559 (CHEMBL4591859) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.389	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Rattus norvegicus (Rat))	BDBM50115640 ((-)-6 5-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2...) Show SMILES COc1cccc2Cc3ccccc3[C@@H]3CN(C)CCN3c12 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Center for Pharmacy Curated by ChEMBL					Assay Description The binding affinity of the compound at 5-hydroxytryptamine 2C receptor was determined using [3H]-mesulergine				J Med Chem 45: 3280-5 (2002) BindingDB Entry DOI: 10.7270/Q28051ZZ
University Center for Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14774 (3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assay				J Med Chem 61: 3870-3888 (2018) Article DOI: 10.1021/acs.jmedchem.7b01670 BindingDB Entry DOI: 10.7270/Q2P84FF9
Vrije Universiteit Amsterdam Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Polycomb protein EED (Homo sapiens (Human))	BDBM50235643 (CHEMBL4076017) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor				Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50000041 ((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...) Show SMILES COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.				J Med Chem 35: 4911-3 (1993) BindingDB Entry DOI: 10.7270/Q2GF0SG7
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Substance-P receptor (Homo sapiens (Human))	BDBM50000041 ((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...) Show SMILES COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.				J Med Chem 35: 4911-3 (1993) BindingDB Entry DOI: 10.7270/Q2GF0SG7
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM217096 (US9302989, 391) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description HTRF assay: This assay used the CisBio HTRF KinEASE kit (kit 62ST2PEZ) and the kinase reaction containing 0.2 uM biotinylated substrate peptide (S2, ...				US Patent US9302989 (2016) BindingDB Entry DOI: 10.7270/Q2HH6HX1
AbbVie Inc. US Patent					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM50597579 (CHEMBL5197201) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00044f BindingDB Entry DOI: 10.7270/Q21C21X0
TBA					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50461413 (CHEMBL1201343) Show SMILES CCCN[C@H]1CCC2N=C(N)SC2C1 \|r,t:8\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Illinois University Edwardsville Curated by ChEMBL					Assay Description Binding affinity to human dopamine D3 receptor				Bioorg Med Chem Lett 28: 1897-1902 (2018) Article DOI: 10.1016/j.bmcl.2018.03.084 BindingDB Entry DOI: 10.7270/Q2F47RS3
					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM50597587 (CHEMBL5174969) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00044f BindingDB Entry DOI: 10.7270/Q21C21X0
TBA					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM50597581 (CHEMBL5183772) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00044f BindingDB Entry DOI: 10.7270/Q21C21X0
TBA					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527525 (CHEMBL4522249) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.513	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50115642 ((+)-65-Methoxy-2-methyl-1,2,3,4,9,13b-hexahydro-2,...) Show SMILES COc1cccc2Cc3ccccc3[C@H]3CN(C)CCN3c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Center for Pharmacy Curated by ChEMBL					Assay Description The binding affinity of the compound at 5-hydroxytryptamine 2A receptor was determined using [3H]-ketanserin				J Med Chem 45: 3280-5 (2002) BindingDB Entry DOI: 10.7270/Q28051ZZ
University Center for Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Isoform 1 of Calcitonin receptor (1) (Homo sapiens (Human))	BDBM50110273 (CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide \| CHEMBL...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rutgers University Curated by ChEMBL					Assay Description Inhibition of [125I]-salmon calcitonin (sCT) binding to human calcitonin receptor I1 expressed in HEK293 cells				J Med Chem 45: 1108-21 (2002) BindingDB Entry DOI: 10.7270/Q2N015V5
Rutgers University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50527529 (CHEMBL4454600) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.562	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based				J Med Chem 63: 3485-3507 (2020) Article DOI: 10.1021/acs.jmedchem.9b00985 BindingDB Entry DOI: 10.7270/Q20005JV
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-K receptor (Homo sapiens (Human))	BDBM50099628 (3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoli...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes				J Med Chem 44: 1675-89 (2001) BindingDB Entry DOI: 10.7270/Q29C6WQN
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)	BDBM50040237 (2-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f]...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Liège Curated by ChEMBL					Assay Description In vitro binding affinity against rat 5-hydroxytryptamine 2 receptor.				J Med Chem 36: 2107-14 (1993) BindingDB Entry DOI: 10.7270/Q22B8X37
University of Liège Curated by ChEMBL					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM50597590 (CHEMBL5185547) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00044f BindingDB Entry DOI: 10.7270/Q21C21X0
TBA					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50427452 (CHEMBL2326941) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assay				J Med Chem 61: 3870-3888 (2018) Article DOI: 10.1021/acs.jmedchem.7b01670 BindingDB Entry DOI: 10.7270/Q2P84FF9
Vrije Universiteit Amsterdam Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM523801 (US11136312, Compound SK-I-128) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.632	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
TBA					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM523803 (US11136312, Compound SK-I-132) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.646	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DB851B
TBA					More data for this Ligand-Target Pair
Polycomb protein EED (Homo sapiens (Human))	BDBM50235658 (CHEMBL4073166) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor				Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50000040 (((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.				J Med Chem 35: 4911-3 (1993) BindingDB Entry DOI: 10.7270/Q2GF0SG7
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50000040 (((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.				J Med Chem 35: 4911-3 (1993) BindingDB Entry DOI: 10.7270/Q2GF0SG7
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

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