| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
|---|
| Ligand | BDBM50201578 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1623127 (CHEMBL3865479) |
|---|
| EC50 | >20000±n/a nM |
|---|
| Citation |  Guo, L; Parker, DL; Zang, Y; Sweis, RF; Liu, W; Sherer, EC; Buist, N; Terebetski, J; Kelly, T; Bugianesi, R; Priest, BT; Dingley, KH; Li, X; Mitelman, S; Salituro, G; Trujillo, ME; Pachanski, M; Kirkland, M; Powles, MA; Eiermann, GJ; Feng, Y; Shang, J; Howard, AD; Ujjainwalla, F; Sinz, CJ; Debenham, JS; Edmondson, SD; Nargund, RP; Hagmann, WK; Li, D Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. ACS Med Chem Lett7:1107-1111 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Probable G-protein coupled receptor 142 |
|---|
| Name: | Probable G-protein coupled receptor 142 |
|---|
| Synonyms: | G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 51127.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_985961 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQ
VTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATA
GQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVA
LARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFA
ANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMW
RDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILL
GITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKT
FRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
|
|
|
|---|
| BDBM50201578 |
|---|
| n/a |
|---|
| Name | BDBM50201578 |
|---|
| Synonyms: | CHEMBL3940492 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18F2N6O2 |
|---|
| Mol. Mass. | 424.4034 |
|---|
| SMILES | COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc(F)c2F)nn1 |
|---|
| Structure | 
|
|---|
Search and Browse
