| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
|---|
| Ligand | BDBM50381477 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1623128 (CHEMBL3865480) |
|---|
| EC50 | 23±n/a nM |
|---|
| Citation |  Guo, L; Parker, DL; Zang, Y; Sweis, RF; Liu, W; Sherer, EC; Buist, N; Terebetski, J; Kelly, T; Bugianesi, R; Priest, BT; Dingley, KH; Li, X; Mitelman, S; Salituro, G; Trujillo, ME; Pachanski, M; Kirkland, M; Powles, MA; Eiermann, GJ; Feng, Y; Shang, J; Howard, AD; Ujjainwalla, F; Sinz, CJ; Debenham, JS; Edmondson, SD; Nargund, RP; Hagmann, WK; Li, D Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. ACS Med Chem Lett7:1107-1111 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Probable G-protein coupled receptor 142 |
|---|
| Name: | Probable G-protein coupled receptor 142 |
|---|
| Synonyms: | GP142_MOUSE | Gpr142 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40779.27 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_985965 |
|---|
| Residue: | 365 |
|---|
| Sequence: | MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPES
PERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFV
GFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPG
RTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTN
SAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVH
LALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKS
VGTEL
|
|
|
|---|
| BDBM50381477 |
|---|
| n/a |
|---|
| Name | BDBM50381477 |
|---|
| Synonyms: | CHEMBL2017410 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22N6O2 |
|---|
| Mol. Mass. | 438.4812 |
|---|
| SMILES | COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1 |
|---|
| Structure | 
|
|---|
Search and Browse
