| Reaction Details |
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 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
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| Ligand | BDBM50381477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1623127 (CHEMBL3865479) |
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| EC50 | 252±n/a nM |
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| Citation |  Guo, L; Parker, DL; Zang, Y; Sweis, RF; Liu, W; Sherer, EC; Buist, N; Terebetski, J; Kelly, T; Bugianesi, R; Priest, BT; Dingley, KH; Li, X; Mitelman, S; Salituro, G; Trujillo, ME; Pachanski, M; Kirkland, M; Powles, MA; Eiermann, GJ; Feng, Y; Shang, J; Howard, AD; Ujjainwalla, F; Sinz, CJ; Debenham, JS; Edmondson, SD; Nargund, RP; Hagmann, WK; Li, D Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. ACS Med Chem Lett7:1107-1111 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Probable G-protein coupled receptor 142 |
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| Name: | Probable G-protein coupled receptor 142 |
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| Synonyms: | G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51127.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_985961 |
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| Residue: | 462 |
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| Sequence: | MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQ
VTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATA
GQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVA
LARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFA
ANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMW
RDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILL
GITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKT
FRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
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| BDBM50381477 |
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| n/a |
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| Name | BDBM50381477 |
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| Synonyms: | CHEMBL2017410 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6O2 |
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| Mol. Mass. | 438.4812 |
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| SMILES | COc1cc(ccc1-n1cnc(C)c1)-c1cn(CC(=O)Nc2cccc3ccccc23)nn1 |
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| Structure | 
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