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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A | ||
| Ligand | BDBM50232594 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1655339 (CHEMBL4004705) | ||
| IC50 | 9200±n/a nM | ||
| Citation |  King, D; Iwuagwu, C; Cook, J; McDonald, IM; Mate, R; Zusi, FC; Hill, MD; Fang, H; Zhao, R; Wang, B; Easton, AE; Miller, R; Post-Munson, D; Knox, RJ; Gallagher, L; Westphal, R; Molski, T; Fan, J; Clarke, W; Benitex, Y; Lentz, KA; Denton, R; Morgan, D; Zaczek, R; Lodge, NJ; Bristow, LJ; Macor, JE; Olson, RE BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. ACS Med Chem Lett8:366-371 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 55283.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P46098 | ||
| Residue: | 478 | ||
| Sequence: |
| ||
| BDBM50232594 | |||
| n/a | |||
| Name | BDBM50232594 | ||
| Synonyms: | CHEMBL4102566 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21N5O | ||
| Mol. Mass. | 335.4029 | ||
| SMILES | C1N=C(Nc2cc(ncn2)-c2ccccc2)O[C@]11CN2CCC1CC2 |r,wD:17.19,t:1,TLB:0:17:20.21:24.23,THB:16:17:20.21:24.23,(15.47,-25.27,;15.91,-23.79,;14.64,-22.92,;14.61,-21.38,;15.93,-20.58,;15.89,-19.04,;17.21,-18.24,;18.57,-18.98,;18.6,-20.53,;17.28,-21.33,;17.16,-16.7,;18.48,-15.9,;18.45,-14.36,;17.09,-13.62,;15.77,-14.43,;15.82,-15.97,;13.42,-23.85,;13.93,-25.31,;14.79,-26.41,;13.02,-27.37,;12.76,-28.49,;11.95,-27.32,;12.44,-25.93,;11.22,-24.85,;11.51,-26.06,)| | ||
| Structure | 
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