| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial |
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| Ligand | BDBM405078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Di Francesco, ME; Jones, P; Heffernan, T; Hamilton, MM; Kang, Z; Soth, MJ; Burke, JP; Le, K; Carroll, CL; Palmer, WS; Lewis, R; McAfoos, T; Czako, B; Liu, G; Theroff, J; Herrera, Z; Yau, A GLS1 inhibitors for treating disease US Patent US10344025 Publication Date 7/9/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminase kidney isoform, mitochondrial |
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| Name: | Glutaminase kidney isoform, mitochondrial |
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| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
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| Type: | Protein |
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| Mol. Mass.: | 73471.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O94925 |
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| Residue: | 669 |
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| Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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| BDBM405078 |
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| n/a |
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| Name | BDBM405078 |
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| Synonyms: | 1-{2-fluoro-4-[4-({[6- (trifluoromethyl)pyridin-2- yl]methyl}carbamoyl)-1H-1,2,3- triazol-1-yl]butyl}-N-{[-fluoro-5- (trifluoromethoxy)phenyl]methyl}- 1H-1,2,3-triazole-4-carboxamide | US10344025, Example 422 | US11370786, Example 422 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21F8N9O3 |
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| Mol. Mass. | 647.48 |
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| SMILES | FC(CCn1cc(nn1)C(=O)NCc1cccc(n1)C(F)(F)F)Cn1cc(nn1)C(=O)NCc1cc(OC(F)(F)F)ccc1F |
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| Structure | 
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