Reaction Details |
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Target | Isoform C of Beta-secretase 1 (BACE-I-457) |
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Ligand | BDBM113237 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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pH | 4.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 11.2±n/a nM |
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Comments | extracted |
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Citation | Cacatian, S; Claremon, DA; Dillard, LW; Fuchs, K; Heine, N; Jia, L; Leftheris, K; McKeever, B; Morales-Ramos, A; Singh, SB; Venkatraman, S; Wu, G; Wu, Z; Xu, Z; Yuan, J; Zheng, Y Inhibitors of beta-secretase US Patent US8633212 Publication Date 1/21/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform C of Beta-secretase 1 (BACE-I-457) |
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Name: | Isoform C of Beta-secretase 1 (BACE-I-457) |
Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE) | Beta-secretase 1 (BACE-I-457) | KIAA1149 |
Type: | Enzyme |
Mol. Mass.: | 51006.30 |
Organism: | Homo sapiens (Human) |
Description: | P56817-3 |
Residue: | 457 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQ
SEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYD
KSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVI
SLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYV
VFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAA
ICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK
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BDBM113237 |
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n/a |
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Name | BDBM113237 |
Synonyms: | US10336717, Compound 15 | US8633212, 15 | US9212153, 15 |
Type | Small organic molecule |
Emp. Form. | C27H25ClFN3O |
Mol. Mass. | 461.958 |
SMILES | CN1OC2(N=C1N)c1cc(ccc1CC21CCc2ccccc2CC1)-c1cc(F)cc(Cl)c1 |c:4| |
Structure |
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