Reaction Details |
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Target | Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
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Ligand | BDBM5110 |
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Substrate/Competitor | Poly(rC):oligo(dG )Template:Primer |
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Meas. Tech. | HIV-1 RT Assay |
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pH | 8.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 33000±n/a nM |
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Citation | Masuda, N; Yamamoto, O; Fujii, M; Ohgami, T; Fujiyasu, J; Kontani, T; Moritomo, A; Orita, M; Kurihara, H; Koga, H; Nakahara, H; Kageyama, S; Ohta, M; Inoue, H; Hatta, T; Suzuki, H; Sudo, K; Shimizu, Y; Kodama, E; Matsuoka, M; Fujiwara, M; Yokota, T; Shigeta, S; Baba, M Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides. Bioorg Med Chem12:6171-82 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
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Name: | Gag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C] |
Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (Y181C) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [588-1147,Y768C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain A | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 64426.38 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1147,Y768C] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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Component 2 |
Name: | Gag-Pol polyprotein [588-1127,Y768C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 51277.10 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1127,Y768C] |
Residue: | 440 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
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BDBM5110 |
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Poly(rC):oligo(dG )Template:Primer |
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Name: | Poly(rC):oligo(dG )Template:Primer |
Synonyms: | n/a |
Type: | RNA /DNA Duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | The incorporation of Tritium-labeled [3H]dGTP onto a (poly)rC:(oligo)dG template:primer. |
Residue: | 3 |
Sequence: | |