Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM185279 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescent Imaging Plate Reader (FLIPR) Assay |
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Temperature | 310.15±n/a K |
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IC50 | 1067±n/a nM |
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Comments | extracted |
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Citation | Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists US Patent US9156829 Publication Date 10/13/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM185279 |
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n/a |
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Name | BDBM185279 |
Synonyms: | US10011588, Example 95 | US10689373, Example 95 | US9156829, 95 |
Type | Small organic molecule |
Emp. Form. | C21H21F3N6O |
Mol. Mass. | 430.4262 |
SMILES | CC1(CCCC1NC(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F |
Structure |
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