| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polycomb protein EED |
|---|
| Ligand | BDBM223985 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET Binding Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 298.15±0 K |
|---|
| Ki | 4±0.0 nM |
|---|
| Citation |  He, Y; Selvaraju, S; Curtin, ML; Jakob, CG; Zhu, H; Comess, KM; Shaw, B; The, J; Lima-Fernandes, E; Szewczyk, MM; Cheng, D; Klinge, KL; Li, HQ; Pliushchev, M; Algire, MA; Maag, D; Guo, J; Dietrich, J; Panchal, SC; Petros, AM; Sweis, RF; Torrent, M; Bigelow, LJ; Senisterra, G; Li, F; Kennedy, S; Wu, Q; Osterling, DJ; Lindley, DJ; Gao, W; Galasinski, S; Barsyte-Lovejoy, D; Vedadi, M; Buchanan, FG; Arrowsmith, CH; Chiang, GG; Sun, C; Pappano, WN The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol13:389-395 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polycomb protein EED |
|---|
| Name: | Polycomb protein EED |
|---|
| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50201.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75530 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
|
|
|
|---|
| BDBM223985 |
|---|
| n/a |
|---|
| Name | BDBM223985 |
|---|
| Synonyms: | rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine (2) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28FN3 |
|---|
| Mol. Mass. | 365.4869 |
|---|
| SMILES | CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1cn(C)c2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
