Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polycomb protein EED (Homo sapiens (Human)) | BDBM50235631 (CHEMBL4060827) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. Curated by ChEMBL | Assay Description Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay | Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM50235630 (CHEMBL4093096) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. Curated by ChEMBL | Assay Description Inhibition of OG(488) labeled probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay | Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM223987 (A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.400 | -53.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
AbbVie Inc. | Assay Description For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti... | Nat Chem Biol 13: 389-395 (2017) Article DOI: 10.1038/nchembio.2306 BindingDB Entry DOI: 10.7270/Q2NG4PGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM50235643 (CHEMBL4076017) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. Curated by ChEMBL | Assay Description In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor | Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM217096 (US9302989, 391) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. US Patent | Assay Description HTRF assay: This assay used the CisBio HTRF KinEASE kit (kit 62ST2PEZ) and the kinase reaction containing 0.2 uM biotinylated substrate peptide (S2, ... | US Patent US9302989 (2016) BindingDB Entry DOI: 10.7270/Q2HH6HX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM223987 (A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
AbbVie Inc. | Assay Description For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti... | Nat Chem Biol 13: 389-395 (2017) Article DOI: 10.1038/nchembio.2306 BindingDB Entry DOI: 10.7270/Q2NG4PGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM50235658 (CHEMBL4073166) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. Curated by ChEMBL | Assay Description In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor | Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM50235644 (CHEMBL4065766) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. Curated by ChEMBL | Assay Description In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor | Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM50235632 (CHEMBL4077363) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. Curated by ChEMBL | Assay Description In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptor | Bioorg Med Chem Lett 27: 1576-1583 (2017) Article DOI: 10.1016/j.bmcl.2017.02.030 BindingDB Entry DOI: 10.7270/Q22F7QQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196849 (US9212192, 12) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196854 (US9212192, 17) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196855 (US9212192, 18) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196857 (US9212192, 20) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196862 (US9212192, 25) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196863 (US9212192, 26) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196864 (US9212192, 27) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196865 (US9212192, 28) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196866 (US9212192, 29) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196868 (US9212192, 31) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196869 (US9212192, 32) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196870 (US9212192, 33) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196873 (US9212192, 36) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196875 (US9212192, 38) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196877 (US9212192, 40) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196878 (US9212192, 41) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196879 (US9212192, 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM223986 ((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
AbbVie Inc. | Assay Description For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti... | Nat Chem Biol 13: 389-395 (2017) Article DOI: 10.1038/nchembio.2306 BindingDB Entry DOI: 10.7270/Q2NG4PGD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196881 (US9212192, 44) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196885 (US9212192, 48) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196886 (US9212192, 49) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196887 (US9212192, 50) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196888 (US9212192, 51) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196890 (US9212192, 53) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196891 (US9212192, 54) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196897 (US9212192, 60) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196903 (US9212192, 66) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1 | -51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196852 (US9212192, 15) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-51.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM217112 (US9302989, 407) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-... | Bioorg Med Chem Lett 27: 3317-3325 (2017) Article DOI: 10.1016/j.bmcl.2017.06.018 BindingDB Entry DOI: 10.7270/Q2D22123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM217092 (US9302989, 387) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. US Patent | Assay Description HTRF assay: This assay used the CisBio HTRF KinEASE kit (kit 62ST2PEZ) and the kinase reaction containing 0.2 uM biotinylated substrate peptide (S2, ... | US Patent US9302989 (2016) BindingDB Entry DOI: 10.7270/Q2HH6HX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50254198 (CHEMBL4060799) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-... | Bioorg Med Chem Lett 27: 3317-3325 (2017) Article DOI: 10.1016/j.bmcl.2017.06.018 BindingDB Entry DOI: 10.7270/Q2D22123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196880 (US9212192, 43) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.5 | -50.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM217057 (US9302989, 349) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-... | Bioorg Med Chem Lett 27: 3317-3325 (2017) Article DOI: 10.1016/j.bmcl.2017.06.018 BindingDB Entry DOI: 10.7270/Q2D22123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50254199 (CHEMBL4083505) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-... | Bioorg Med Chem Lett 27: 3317-3325 (2017) Article DOI: 10.1016/j.bmcl.2017.06.018 BindingDB Entry DOI: 10.7270/Q2D22123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM217094 (US9302989, 389) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc. US Patent | Assay Description HTRF assay: This assay used the CisBio HTRF KinEASE kit (kit 62ST2PEZ) and the kinase reaction containing 0.2 uM biotinylated substrate peptide (S2, ... | US Patent US9302989 (2016) BindingDB Entry DOI: 10.7270/Q2HH6HX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50254216 (CHEMBL4096471) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged human recombinant NAMPT using FK866 or isoindoline urea-based Oregon green (488) probe incubated for 3 hrs by TR-... | Bioorg Med Chem Lett 27: 3317-3325 (2017) Article DOI: 10.1016/j.bmcl.2017.06.018 BindingDB Entry DOI: 10.7270/Q2D22123 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse)) | BDBM50202094 (CHEMBL375341 | N-(5-hydroxy-adamantan-2-yl)-2-(3-t...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPA | J Med Chem 50: 149-64 (2007) Article DOI: 10.1021/jm0609364 BindingDB Entry DOI: 10.7270/Q2Z60NQN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196856 (US9212192, 19) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196876 (US9212192, 39) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196884 (US9212192, 47) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196892 (US9212192, 55) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair |
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