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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polycomb protein EED (EED) | ||
| Ligand | BDBM223986 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TR-FRET Binding Assay | ||
| pH | 7.5±0 | ||
| Temperature | 298.15±0 K | ||
| Ki | 1±0.0 nM | ||
| Citation |  He Y; Selvaraju S; Curtin ML; Jakob CG; Zhu H; Comess KM; Shaw B; The J; Lima-Fernandes E; Szewczyk MM; Cheng D; Klinge KL; Li HQ; Pliushchev M; Algire MA; Maag D; Guo J; Dietrich J; Panchal SC; Petros AM; Sweis RF; Torrent M; Bigelow LJ; Senisterra G; Li F; Kennedy S; Wu Q; Osterling DJ; Lindley DJ; Gao W; Galasinski S; Barsyte-Lovejoy D; Vedadi M; Buchanan FG; Arrowsmith CH; Chiang GG; Sun C; Pappano WN The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol 13:389-395 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polycomb protein EED (EED) | |||
| Name: | EZH2/SUZ12/EED/RBBP7/RBBP4 | ||
| Synonyms: | EED | Polycomb protein EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED | ||
| Type: | Protein | ||
| Mol. Mass.: | 50201.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75530 | ||
| Residue: | 441 | ||
| Sequence: |
| ||
| BDBM223986 | |||
| n/a | |||
| Name | BDBM223986 | ||
| Synonyms: | (3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine (3) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28FN3 | ||
| Mol. Mass. | 377.4976 | ||
| SMILES | CN(C)[C@H]1CN(C[C@@H]1c1cn(C)c2ccccc12)[C@H]1CCc2cccc(F)c12 |r| | ||
| Structure | 
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