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Target5-hydroxytryptamine receptor 6
LigandBDBM236530
Substrate/Competitorn/a
Meas. Tech.Radioligand-Binding Assay
pH7.4±0
Temperature310.15±0 K
Ki 73.2±0.0 nM
Citation Nirogi, RVKambhampati, RKothmirkar, PKonda, JBandyala, TRGudla, PArepalli, SGangadasari, NPShinde, AKDeshpande, ADDwarampudi, AChindhe, AKDubey, PK Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands. J Enzyme Inhib Med Chem27:443-50 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 6
Name:5-hydroxytryptamine receptor 6
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:P50406
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM236530
n/a
NameBDBM236530
Synonyms:2-Isopropoxy-10-[(2-N,N-dimethylamino-2-methyl)ethyl]isoindolo[2,1-a] indole (21)
TypeSmall organic molecule
Emp. Form.C24H29NO
Mol. Mass.347.4932
SMILESCC(C)Oc1ccc2C3Cc4ccccc4C3=C(CC(C)N(C)C)c2c1 |t:18|
Structure
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