| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM236539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand-Binding Assay |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| Ki | 37.6±0.0 nM |
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| Citation |  Nirogi, RV; Kambhampati, R; Kothmirkar, P; Konda, J; Bandyala, TR; Gudla, P; Arepalli, S; Gangadasari, NP; Shinde, AK; Deshpande, AD; Dwarampudi, A; Chindhe, AK; Dubey, PK Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands. J Enzyme Inhib Med Chem27:443-50 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46968.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50406 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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| BDBM236539 |
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| n/a |
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| Name | BDBM236539 |
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| Synonyms: | 2-Fluoro-7-chloro-10-(2-N,N-dimethylaminoethyl)isoindolo[2,1-a]indole (30) |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19ClFN |
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| Mol. Mass. | 327.823 |
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| SMILES | CN(C)CCC1=C2C(Cc3cc(Cl)ccc23)c2ccc(F)cc12 |t:5| |
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| Structure | 
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