Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM256961 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescent Imaging Plate Reader (FLIPR) Assay |
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Temperature | 310.15±n/a K |
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IC50 | 21±n/a nM |
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Comments | extracted |
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Citation | Fieldhouse, C; Glen, A; Robinson, JS; Fujimoto, T Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disorders US Patent US9493432 Publication Date 11/15/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM256961 |
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n/a |
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Name | BDBM256961 |
Synonyms: | US9493432, 87 |
Type | Small organic molecule |
Emp. Form. | C21H19FN6O2 |
Mol. Mass. | 406.413 |
SMILES | Fc1ccc2nc(N[C@H]3CCC[C@@H]3NC(=O)c3ccccc3-n3nccn3)oc2c1 |r| |
Structure |
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