Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM256898 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescent Imaging Plate Reader (FLIPR) Assay |
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Temperature | 310.15±n/a K |
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IC50 | 8600±n/a nM |
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Comments | extracted |
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Citation | Fieldhouse, C; Glen, A; Robinson, JS; Fujimoto, T Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disorders US Patent US9493432 Publication Date 11/15/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM256898 |
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n/a |
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Name | BDBM256898 |
Synonyms: | US9493432, 22 |
Type | Small organic molecule |
Emp. Form. | C28H27ClN4O5S |
Mol. Mass. | 567.056 |
SMILES | COc1cccc(OC)c1C(=O)NC1CN(CC1Nc1nc2ccc(Cl)cc2s1)C(=O)OCc1ccccc1 |
Structure |
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