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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM259485 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | hERG-Channel Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 308.15±n/a K | ||
| IC50 | 10000±n/a nM | ||
| Comments | extracted | ||
| Citation |  Bukhtiyarov, Y; Cacatian, S; Dillard, LW; Dorner-Ciossek, C; Fuchs, K; Jia, L; Lala, DS; Morales-Ramos, A; Reeves, J; Singh, SB; Venkatraman, S; Xu, Z; Yuan, J; Zhao, Y; Zheng, Y; Rast, G Inhibitors of beta-secretase US Patent US9526727 Publication Date 12/27/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
| ||
| BDBM259485 | |||
| n/a | |||
| Name | BDBM259485 | ||
| Synonyms: | US9526727, Comparison Example Table 2, 2''-amino-4-methoxy-5''-oxo-1''-(oxolan-2-ylmethyl)-1'',5''-dihydro-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-imidazole]-6'-carbonitrile | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H28N4O3 | ||
| Mol. Mass. | 408.4934 | ||
| SMILES | CO[C@H]1CCC2(Cc3ccc(cc3C22N=C(N)N(CC3CCCO3)C2=O)C#N)CC1 |r,wD:2.1,t:16,(6.55,-1.05,;5.78,-2.39,;4.24,-2.39,;3.47,-1.05,;1.93,-1.05,;1.16,-2.39,;.25,-3.63,;-1.21,-3.16,;-2.55,-3.93,;-3.88,-3.16,;-3.88,-1.62,;-2.55,-.85,;-1.21,-1.62,;.25,-1.14,;-1.21,-.67,;-1.21,.87,;-2.55,1.64,;.25,1.35,;1.02,2.68,;2.56,2.68,;3.47,1.44,;4.93,1.91,;4.93,3.45,;3.47,3.93,;1.16,.1,;2.7,.1,;-5.21,-.85,;-6.55,-.08,;1.93,-3.72,;3.47,-3.72,)| | ||
| Structure | 
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