| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-1 |
|---|
| Ligand | BDBM280350 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| IC50 | 50.8±n/a nM |
|---|
| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10501436 Publication Date 12/10/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-1 |
|---|
| Name: | TGF-beta receptor type-1 |
|---|
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I |
|---|
| Type: | enzyme |
|---|
| Mol. Mass.: | 55968.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36897 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
|
|
|
|---|
| BDBM280350 |
|---|
| n/a |
|---|
| Name | BDBM280350 |
|---|
| Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-methyl-ethyl)-4-pyridyl]amino]-N-(2-hydroxypropyl)pyridine-3-carboxamide | US10030004, Compound 17a | US10501436, Compound 17a | US11053216, Compound 17a | US11702401, Compound 17a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26ClFN4O3 |
|---|
| Mol. Mass. | 472.94 |
|---|
| SMILES | COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F |
|---|
| Structure | 
|
|---|
Search and Browse
