Reaction Details |
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Target | Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] |
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Ligand | BDBM296818 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | 11.0±n/a nM |
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Citation | Andrews, SW; Aronow, S; Blake, JF; Brandhuber, BJ; Cook, A; Haas, J; Jiang, Y; Kolakowski, GR; McFaddin, EA; McKenney, ML; McNulty, OT; Metcalf, AT; Moreno, DA; Tang, TP; Ren, L Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors US Patent US10555944 Publication Date 2/11/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] |
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Name: | Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] |
Synonyms: | CDHF12 | CDHR16 | PTC | Proto-oncogene tyrosine-protein kinase receptor Ret (658-end) | Proto-oncogene tyrosine-protein kinase receptor Ret (V804M) | RET | RET Kinase (V804M) (aa658-end) | RET51 | RET_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51567.23 |
Organism: | Homo sapiens (Human) |
Description: | P07949[658-1114,V804M] |
Residue: | 457 |
Sequence: | HCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIMEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS
LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD
LAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL
TRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
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BDBM296818 |
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n/a |
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Name | BDBM296818 |
Synonyms: | US10112942, Example 553 | US10137124, Example 553 | US10172851, Example 553 | US10555944, Example 553 | US10953005, Example 553 |
Type | Small organic molecule |
Emp. Form. | C28H28FN9O2 |
Mol. Mass. | 541.5794 |
SMILES | COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 |
Structure |
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