Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 | ||
Ligand | BDBM451058 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | EED LC-MS Assay | ||
IC50 | 11.7±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 | |||
Name: | Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 | ||
Synonyms: | EZH2/SUZ12/EED complex | Polycomb Repressive Complex 2 (PRC2) | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 3 components. | ||
Component 1 | |||
Name: | Polycomb protein EED | ||
Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED | ||
Type: | Protein | ||
Mol. Mass.: | 50201.68 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75530 | ||
Residue: | 441 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Histone-lysine N-methyltransferase EZH2 | ||
Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
Type: | Protein | ||
Mol. Mass.: | 85367.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910 | ||
Residue: | 746 | ||
Sequence: |
| ||
Component 3 | |||
Name: | Polycomb protein SUZ12 | ||
Synonyms: | CHET9 | ChET 9 protein | Chromatin precipitated E2F target 9 protein | JJAZ1 | Joined to JAZF1 protein | KIAA0160 | Polycomb protein SUZ12 | Polycomb protein SUZ12 (SUZ12) | SUZ12 | SUZ12_HUMAN | Suppressor of zeste 12 protein homolog | ||
Type: | Protein | ||
Mol. Mass.: | 83080.09 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15022 | ||
Residue: | 739 | ||
Sequence: |
| ||
BDBM451058 | |||
n/a | |||
Name | BDBM451058 | ||
Synonyms: | 5-(((5-fluoro-2,3-dihydrobenzofuran-4- | US10676479, Example 88 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H22FN7O2 | ||
Mol. Mass. | 447.4649 | ||
SMILES | Cc1nn(CCO)c(C)c1-c1cnc(NCc2c3CCOc3ccc2F)n2cnc(C#N)c12 |(-3.1,-2.88,;-3.49,-1.39,;-4.96,-.92,;-4.96,.62,;-6.29,1.39,;-7.63,.62,;-8.96,1.39,;-3.49,1.1,;-3.1,2.58,;-2.59,-.15,;-1.05,-.15,;-.28,1.18,;1.26,1.18,;2.03,-.15,;3.57,-.15,;4.34,1.18,;5.88,1.18,;6.65,-.15,;6.17,-1.61,;7.42,-2.52,;8.67,-1.61,;8.19,-.15,;8.96,1.18,;8.19,2.52,;6.65,2.52,;5.88,3.85,;1.26,-1.48,;1.74,-2.95,;.49,-3.85,;-.76,-2.95,;-2.24,-3.35,;-3.73,-3.74,;-.28,-1.48,)| | ||
Structure | ![]() |