| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM403169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic DELFIA Assay |
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| IC50 | 0.200±n/a nM |
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| Citation |  Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Bicyclic-fused heteroaryl or aryl compounds US Patent US10793579 Publication Date 10/6/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM403169 |
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| n/a |
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| Name | BDBM403169 |
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| Synonyms: | US10329302, Example 323 | US10793579, Example 323 | US11702424, Example 323 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18FN3O4 |
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| Mol. Mass. | 359.3516 |
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| SMILES | COc1cc2c(OC[C@H]3NC(=O)[C@]4(F)[C@@H](C)[C@H]34)ccnc2cc1C(N)=O |r| |
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| Structure | 
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