Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Ligand | BDBM490565 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzymatic Assay |
---|
IC50 | 3.20±n/a nM |
---|
Citation | Gradl, SN; Nguyen, D; Eis, K; Günther, J; Stellfeld, T; Janzer, A; Christian, S; Mueller, T; Sheikh, SE; Zhou, HJ; Zhao, C; Sykes, DB; Ferrara, SJ; Liu, K; Herbert, SA; Merz, C; Niehues, M; Nising, CF; Schäfer, M; Zimmermann, K; Knäblein, J; Thede, K; Faupel, T 4,5-annulated 1,2,4-triazolones US Patent US10968216 Publication Date 4/6/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
BDBM490565 |
---|
n/a |
---|
Name | BDBM490565 |
Synonyms: | N-(2-chloro-6-methylphenyl)-5-fluoro-4-(3-oxo-6,7-dihydro-3H,5H-[1,2,4]triazolo[3,4-c]-[1,4]oxazepin-2(9H)-yl)-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide | US10968216, Example 233 |
Type | Small organic molecule |
Emp. Form. | C23H21ClF4N4O4 |
Mol. Mass. | 528.884 |
SMILES | C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1Cl)-n1nc2COCCCn2c1=O)C(F)(F)F |r| |
Structure |
|