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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493067 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.100±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
| ||
| BDBM493067 | |||
| n/a | |||
| Name | BDBM493067 | ||
| Synonyms: | 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(cyanomethyl)phenyl)acetamide | US10981911, Example 8 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H25N7O | ||
| Mol. Mass. | 451.523 | ||
| SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccc(CC#N)cc1 |r,wU:18.21,wD:15.17,(-5.97,-1.63,;-5.2,-.29,;-3.66,-.29,;-2.89,-1.63,;-3.52,-3.03,;-2.37,-4.06,;-2.37,-5.6,;-1.04,-6.37,;.29,-5.6,;1.76,-6.08,;2.66,-4.83,;1.76,-3.59,;.29,-4.06,;-1.04,-3.29,;-1.36,-1.79,;-.27,-.7,;1.22,-1.1,;2.31,-.01,;1.91,1.48,;3,2.57,;4.48,2.17,;5.97,1.77,;.42,1.88,;-.67,.79,;-5.97,1.04,;-5.2,2.37,;-3.66,2.37,;-2.89,3.71,;-3.66,5.04,;-2.89,6.37,;-1.35,6.37,;.19,6.37,;-5.2,5.04,;-5.97,3.71,)| | ||
| Structure | 
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