Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
Ligand | BDBM493070 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 0.100±n/a nM | ||
Citation | Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 [574-1154] | |||
Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 66641.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458[574-1154] | ||
Residue: | 581 | ||
Sequence: |
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BDBM493070 | |||
n/a | |||
Name | BDBM493070 | ||
Synonyms: | 2-((1r,4r)-4-(2-(Oxazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 11 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H18N6O | ||
Mol. Mass. | 346.3858 | ||
SMILES | N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cocn1 |r,wU:3.2,wD:6.9,(5.55,3.67,;4.06,4.07,;2.57,4.47,;1.48,3.38,;1.88,1.89,;.79,.81,;-.69,1.2,;-1.09,2.69,;-0,3.78,;-1.78,.12,;-3.31,.28,;-3.94,-1.13,;-2.8,-2.16,;-2.8,-3.7,;-1.46,-4.47,;-.13,-3.7,;1.34,-4.18,;2.24,-2.93,;1.34,-1.69,;-.13,-2.16,;-1.46,-1.39,;-4.08,1.61,;-5.55,2.09,;-5.55,3.63,;-4.08,4.1,;-3.18,2.86,)| | ||
Structure |