Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
Ligand | BDBM493072 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 0.100±n/a nM | ||
Citation | Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 [574-1154] | |||
Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 66641.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458[574-1154] | ||
Residue: | 581 | ||
Sequence: |
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BDBM493072 | |||
n/a | |||
Name | BDBM493072 | ||
Synonyms: | 2-Cyano-N-((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)ethanesulfonamide | US10981911, Example 13 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23N7O2S | ||
Mol. Mass. | 425.507 | ||
SMILES | O=S(=O)(CCC#N)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:24.27,wD:21.23,(-3.28,1.12,;-4.82,1.12,;-6.36,1.12,;-4.82,2.66,;-6.15,3.43,;-6.15,4.97,;-6.15,6.51,;-4.82,-.42,;-3.28,-.42,;-2.51,-1.76,;-3.13,-3.17,;-1.99,-4.2,;-1.99,-5.74,;-.65,-6.51,;.68,-5.74,;2.14,-6.21,;3.05,-4.97,;2.14,-3.72,;.68,-4.2,;-.65,-3.43,;-.97,-1.92,;.11,-.83,;1.6,-1.23,;2.69,-.14,;2.29,1.35,;3.38,2.44,;4.87,2.04,;6.36,1.64,;.8,1.75,;-.28,.66,)| | ||
Structure |