Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 [512-1124] | ||
| Ligand | BDBM493073 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 43.7±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 [512-1124] | |||
| Name: | Tyrosine-protein kinase JAK3 [512-1124] | ||
| Synonyms: | JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 68951.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333[512-1124] | ||
| Residue: | 613 | ||
| Sequence: |
| ||
| BDBM493073 | |||
| n/a | |||
| Name | BDBM493073 | ||
| Synonyms: | 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(pyrimidin-4-ylmethyl)acetamide | US10981911, Example 14 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24N8O | ||
| Mol. Mass. | 428.4897 | ||
| SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccncn1 |r,wU:18.21,wD:15.17,(-3.66,-.96,;-2.89,.37,;-1.35,.37,;-.58,-.96,;-1.21,-2.37,;-.06,-3.4,;-.06,-4.94,;1.27,-5.71,;2.6,-4.94,;4.07,-5.41,;4.97,-4.17,;4.07,-2.92,;2.6,-3.4,;1.27,-2.63,;.95,-1.12,;2.04,-.03,;3.53,-.43,;4.62,.66,;4.22,2.15,;5.31,3.23,;6.79,2.84,;8.28,2.44,;2.73,2.54,;1.64,1.45,;-3.66,1.71,;-5.2,1.71,;-5.97,3.04,;-7.51,3.04,;-8.28,4.37,;-7.51,5.71,;-5.97,5.71,;-5.2,4.37,)| | ||
| Structure | 
| ||