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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493074 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.100±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
| ||
| BDBM493074 | |||
| n/a | |||
| Name | BDBM493074 | ||
| Synonyms: | 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(3-hydroxy-2,2-dimethylpropyl)acetamide | US10981911, Example 15 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H30N6O2 | ||
| Mol. Mass. | 422.5233 | ||
| SMILES | CC(C)(CO)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:25.28,wD:22.24,(-5.57,-2.54,;-5.97,-1.05,;-4.64,-1.82,;-7.51,-1.05,;-8.28,-2.38,;-5.2,.28,;-3.66,.28,;-2.89,1.62,;-3.66,2.95,;-1.35,1.62,;-.58,.28,;-1.21,-1.12,;-.07,-2.16,;-.08,-3.7,;1.25,-4.47,;2.59,-3.71,;4.05,-4.19,;4.96,-2.95,;4.06,-1.7,;2.59,-2.17,;1.26,-1.39,;.95,.12,;2.04,1.2,;3.53,.81,;4.62,1.9,;4.22,3.38,;5.31,4.47,;6.79,4.07,;8.28,3.67,;2.73,3.78,;1.64,2.69,)| | ||
| Structure | 
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