Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
Ligand | BDBM493084 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 0.100±n/a nM | ||
Citation | Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 [574-1154] | |||
Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 66641.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458[574-1154] | ||
Residue: | 581 | ||
Sequence: |
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BDBM493084 | |||
n/a | |||
Name | BDBM493084 | ||
Synonyms: | 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((3-hydroxyoxetan-3-yl)methyl)acetamide | US10981911, Example 24 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H26N6O3 | ||
Mol. Mass. | 422.4802 | ||
SMILES | OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)COC1 |r,wU:22.25,wD:19.21,(-7.79,-.28,;-6.46,-1.05,;-5.69,.28,;-4.15,.28,;-3.38,1.62,;-4.15,2.95,;-1.84,1.62,;-1.07,.28,;-1.7,-1.12,;-.56,-2.16,;-.57,-3.7,;.76,-4.47,;2.1,-3.71,;3.56,-4.19,;4.47,-2.95,;3.57,-1.7,;2.11,-2.17,;.78,-1.39,;.46,.12,;1.55,1.2,;3.04,.81,;4.13,1.9,;3.73,3.38,;4.82,4.47,;6.31,4.07,;7.79,3.67,;2.24,3.78,;1.15,2.69,;-7.23,-2.38,;-5.9,-3.15,;-5.13,-1.82,)| | ||
Structure |