Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
Ligand | BDBM387826 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 0.200±n/a nM | ||
Citation | Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 [574-1154] | |||
Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 66641.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458[574-1154] | ||
Residue: | 581 | ||
Sequence: |
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BDBM387826 | |||
n/a | |||
Name | BDBM387826 | ||
Synonyms: | 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1-methyl-1H-pyrazol-4-yl)acetamide | US10294226, Compound Ex. 9 | US10487083, Example 9 | US10981911, Example 38 | US11059823, Example 9 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H24N8O | ||
Mol. Mass. | 416.479 | ||
SMILES | Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cn1 |r,wU:23.26,wD:20.22,(-8.49,1.71,;-7.16,.94,;-5.7,1.41,;-4.79,.17,;-3.25,.17,;-2.48,1.5,;-3.25,2.83,;-.94,1.5,;-.17,.17,;-.8,-1.24,;.35,-2.27,;.35,-3.81,;1.68,-4.58,;3.01,-3.81,;4.48,-4.29,;5.38,-3.04,;4.48,-1.8,;3.01,-2.27,;1.68,-1.5,;1.36,0,;2.39,1.15,;3.9,.83,;4.93,1.97,;4.45,3.44,;5.48,4.58,;6.99,4.26,;8.49,3.94,;2.95,3.76,;1.91,2.61,;-5.7,-1.08,;-7.16,-.6,)| | ||
Structure |