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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 [512-1124] | ||
| Ligand | BDBM493100 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 47.0±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 [512-1124] | |||
| Name: | Tyrosine-protein kinase JAK3 [512-1124] | ||
| Synonyms: | JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 68951.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333[512-1124] | ||
| Residue: | 613 | ||
| Sequence: |
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| BDBM493100 | |||
| n/a | |||
| Name | BDBM493100 | ||
| Synonyms: | 1-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)urea | US10981911, Example 40 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H21N7O | ||
| Mol. Mass. | 351.4056 | ||
| SMILES | NC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:20.23,wD:17.19,(-6.64,2.83,;-5.1,2.83,;-4.33,4.17,;-4.33,1.5,;-2.79,1.5,;-2.02,.17,;-2.65,-1.24,;-1.5,-2.27,;-1.5,-3.81,;-.17,-4.58,;1.16,-3.81,;2.63,-4.29,;3.53,-3.04,;2.63,-1.8,;1.16,-2.27,;-.17,-1.5,;-.49,0,;.54,1.15,;2.05,.83,;3.08,1.97,;2.6,3.44,;3.63,4.58,;5.14,4.26,;6.64,3.94,;1.09,3.76,;.06,2.61,)| | ||
| Structure | 
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