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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493101 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | <0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
| ||
| BDBM493101 | |||
| n/a | |||
| Name | BDBM493101 | ||
| Synonyms: | 2-((1r,4r)-4-(2-(Thiazol-4-ylmethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 41 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H20N6S | ||
| Mol. Mass. | 376.478 | ||
| SMILES | N#CC[C@H]1CC[C@@H](CC1)n1c(Cc2cscn2)nc2cnc3[nH]ccc3c12 |r,wU:3.2,wD:6.9,(6.67,3.94,;5.17,4.26,;3.66,4.58,;2.63,3.44,;3.11,1.97,;2.08,.83,;.57,1.15,;.09,2.61,;1.12,3.76,;-.46,0,;-1.99,.17,;-2.76,1.5,;-4.3,1.5,;-5.21,2.74,;-6.67,2.27,;-6.67,.73,;-5.21,.25,;-2.62,-1.24,;-1.48,-2.27,;-1.48,-3.81,;-.14,-4.58,;1.19,-3.81,;2.66,-4.29,;3.56,-3.04,;2.66,-1.8,;1.19,-2.27,;-.14,-1.5,)| | ||
| Structure | 
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