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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM50527406 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
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| BDBM50527406 | |||
| n/a | |||
| Name | BDBM50527406 | ||
| Synonyms: | CHEMBL4588333 | US10981911, Example 45 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H25FN6O | ||
| Mol. Mass. | 444.504 | ||
| SMILES | Fc1ccc(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1 |r,wU:22.24,wD:25.28,(4.15,-4.61,;4.92,-5.95,;6.47,-5.94,;7.24,-7.28,;6.46,-8.6,;7.24,-9.93,;8.78,-9.93,;9.55,-11.26,;8.78,-12.6,;11.09,-11.26,;11.86,-12.6,;11.24,-14,;12.38,-15.02,;12.38,-16.56,;13.71,-17.33,;15.04,-16.56,;16.52,-17.04,;17.43,-15.79,;16.52,-14.53,;15.04,-15.01,;13.7,-14.25,;13.38,-12.75,;14.41,-11.61,;13.94,-10.15,;14.97,-9,;16.48,-9.33,;17.52,-8.18,;19.02,-8.51,;20.53,-8.84,;16.95,-10.79,;15.93,-11.93,;4.93,-8.62,;4.16,-7.29,)| | ||
| Structure | 
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