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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493108 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
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| BDBM493108 | |||
| n/a | |||
| Name | BDBM493108 | ||
| Synonyms: | N-Benzyl-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide | US10981911, Example 48 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H26N6O | ||
| Mol. Mass. | 426.5135 | ||
| SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccccc1 |r,wU:18.21,wD:15.17,(-3.55,-.96,;-2.78,.37,;-1.24,.37,;-.47,-.96,;-1.1,-2.37,;.04,-3.4,;.04,-4.94,;1.38,-5.71,;2.71,-4.94,;4.18,-5.41,;5.08,-4.17,;4.18,-2.92,;2.71,-3.4,;1.38,-2.63,;1.06,-1.12,;2.09,.02,;3.59,-.3,;4.63,.85,;4.15,2.31,;5.18,3.46,;6.69,3.14,;8.17,2.74,;2.64,2.63,;1.61,1.49,;-3.55,1.71,;-5.09,1.71,;-5.86,3.04,;-5.09,4.37,;-5.86,5.71,;-7.4,5.71,;-8.17,4.37,;-7.4,3.04,)| | ||
| Structure | 
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