Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493109 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
| ||
| BDBM493109 | |||
| n/a | |||
| Name | BDBM493109 | ||
| Synonyms: | 2-((1r,4r)-4-(2-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 49 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O | ||
| Mol. Mass. | 390.4814 | ||
| SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCCC1 |r,wU:18.21,wD:15.17,(-4.94,-.18,;-4.17,1.15,;-2.63,1.15,;-1.86,-.18,;-2.48,-1.59,;-1.34,-2.62,;-1.34,-4.16,;-.01,-4.93,;1.33,-4.16,;2.79,-4.63,;3.7,-3.39,;2.79,-2.14,;1.33,-2.62,;-.01,-1.85,;-.33,-.34,;.7,.8,;2.21,.48,;3.24,1.63,;2.77,3.09,;3.8,4.24,;5.3,3.92,;6.79,3.52,;1.26,3.41,;.23,2.27,;-4.94,2.49,;-4.31,3.9,;-5.46,4.93,;-6.79,4.16,;-6.47,2.65,)| | ||
| Structure | 
| ||