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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493111 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
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| BDBM493111 | |||
| n/a | |||
| Name | BDBM493111 | ||
| Synonyms: | 2-((1r,4r)-4-(2-(2-Aminopyrimidin-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 51 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H20N8 | ||
| Mol. Mass. | 372.4264 | ||
| SMILES | Nc1ncc(cn1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:22.26,wD:19.22,(-5.86,5.04,;-5.09,3.71,;-3.55,3.71,;-2.78,2.37,;-3.55,1.04,;-5.09,1.04,;-5.86,2.37,;-2.78,-.29,;-3.41,-1.7,;-2.27,-2.73,;-2.27,-4.27,;-.93,-5.04,;.4,-4.27,;1.87,-4.75,;2.77,-3.5,;1.87,-2.26,;.4,-2.73,;-.93,-1.96,;-1.25,-.45,;-.22,.69,;1.28,.37,;2.32,1.51,;1.84,2.98,;2.87,4.12,;4.38,3.8,;5.86,3.4,;.33,3.3,;-.7,2.15,)| | ||
| Structure | 
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