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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493113 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
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| BDBM493113 | |||
| n/a | |||
| Name | BDBM493113 | ||
| Synonyms: | 2-((1r,4r)-4-(2-(2-Aminopyrimidin-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 53 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H20N8 | ||
| Mol. Mass. | 372.4264 | ||
| SMILES | Nc1nccc(n1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:22.26,wD:19.22,(-6.63,2.83,;-5.09,2.83,;-4.32,4.17,;-2.78,4.17,;-2.01,2.83,;-2.78,1.5,;-4.32,1.5,;-2.01,.17,;-2.64,-1.24,;-1.5,-2.27,;-1.5,-3.81,;-.16,-4.58,;1.17,-3.81,;2.64,-4.29,;3.54,-3.04,;2.64,-1.8,;1.17,-2.27,;-.16,-1.5,;-.48,0,;.55,1.15,;2.05,.83,;3.09,1.97,;2.61,3.44,;3.64,4.58,;5.15,4.26,;6.63,3.86,;1.1,3.76,;.07,2.61,)| | ||
| Structure | 
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