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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Ligand | BDBM493116 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 0.200±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 [574-1154] | |||
| Name: | Tyrosine-protein kinase JAK1 [574-1154] | ||
| Synonyms: | JAK1 | JAK1 (aa 574-1154) | JAK1A | JAK1B | JAK1_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 66641.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458[574-1154] | ||
| Residue: | 581 | ||
| Sequence: |
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| BDBM493116 | |||
| n/a | |||
| Name | BDBM493116 | ||
| Synonyms: | 2-((1r,4r)-4-(2-(1H-Imidazol-2-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 56 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H19N7 | ||
| Mol. Mass. | 345.4011 | ||
| SMILES | N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1ncc[nH]1 |r,wU:3.2,wD:6.9,(5.63,3.86,;4.15,4.26,;2.64,4.58,;1.61,3.44,;2.09,1.97,;1.06,.83,;-.45,1.15,;-.93,2.61,;.1,3.76,;-1.48,0,;-3.01,.17,;-3.64,-1.24,;-2.49,-2.27,;-2.49,-3.81,;-1.16,-4.58,;.17,-3.81,;1.64,-4.29,;2.54,-3.04,;1.64,-1.8,;.17,-2.27,;-1.16,-1.5,;-3.78,1.5,;-3.16,2.91,;-4.3,3.94,;-5.63,3.17,;-5.31,1.66,)| | ||
| Structure | 
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