| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
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| Ligand | BDBM633584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro DPP1 Enzyme Activity Assay |
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| IC50 | 4.90±n/a nM |
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| Citation |  Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof US Patent US11807635 Publication Date 11/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 1 |
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| Name: | Dipeptidyl peptidase 1 |
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| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51857.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53634 |
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| Residue: | 463 |
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| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
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| BDBM633584 |
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| n/a |
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| Name | BDBM633584 |
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| Synonyms: | (S)—N—((S)-1-cyano-2-(4′-cyano-3-fluoro-3′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)-1,4-oxazepane-2-carboxamide | US11807635, Compound 29 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20F4N4O2 |
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| Mol. Mass. | 460.4241 |
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| SMILES | Fc1cc(ccc1C[C@H](NC(=O)[C@@H]1CNCCCO1)C#N)-c1ccc(C#N)c(c1)C(F)(F)F |r| |
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| Structure | 
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