| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
|---|
| Ligand | BDBM633585 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro DPP1 Enzyme Activity Assay |
|---|
| IC50 | 4.00±n/a nM |
|---|
| Citation |  Li, Y; Shi, Z; Zhang, G; Chen, L; Wang, W; Zhang, X; Zheng, D; Xu, B; Liu, X; Wang, Y; Ye, F; Tang, P; Ni, J; Zhang, C; Yan, P Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof US Patent US11807635 Publication Date 11/7/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 1 |
|---|
| Name: | Dipeptidyl peptidase 1 |
|---|
| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51857.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53634 |
|---|
| Residue: | 463 |
|---|
| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
|
|---|
| BDBM633585 |
|---|
| n/a |
|---|
| Name | BDBM633585 |
|---|
| Synonyms: | US11807635, Compound 35 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22FN5O4 |
|---|
| Mol. Mass. | 439.4396 |
|---|
| SMILES | Cn1c2cc(ccc2oc1=O)-c1cc(F)c(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
