| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] |
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| Ligand | BDBM305738 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | A RET Enzyme Assay |
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| IC50 | 50.0±n/a nM |
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| Citation |  Andrews, SW; Aronow, S; Blake, JF; Brandhuber, BJ; Collier, J; Cook, A; Haas, J; Jiang, Y; Kolakowski, GR; McFaddin, EA; McKenney, ML; McNulty, OT; Metcalf, AT; Moreno, DA; Ramann, GA; Tang, TP; Ren, L; Walls, SM Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors US Patent US10172845 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] |
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| Name: | Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] |
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| Synonyms: | CDHF12 | CDHR16 | PTC | Proto-oncogene tyrosine-protein kinase receptor Ret (658-end) | Proto-oncogene tyrosine-protein kinase receptor Ret (V804M) | RET | RET Kinase (V804M) (aa658-end) | RET51 | RET_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51567.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07949[658-1114,V804M] |
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| Residue: | 457 |
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| Sequence: | HCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIMEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS
LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD
LAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL
TRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
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| BDBM305738 |
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| n/a |
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| Name | BDBM305738 |
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| Synonyms: | 6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiperidin-1- yl)pyridin-3-yl) pyrazolo[1,5-a]pyridine- 3-carbonitrile | US10144734, Example 756 | US10172845, Example 756 | US10441581, Example 756 | US10881652, Example 756 | US11648243, Example 756 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26FN5O2 |
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| Mol. Mass. | 471.526 |
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| SMILES | CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N |
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| Structure | 
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