| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] |
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| Ligand | BDBM14795 |
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| Substrate/Competitor | BDBM10851 |
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| Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 840±n/a nM |
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| Citation |  Card, GL; Blasdel, L; England, BP; Zhang, C; Suzuki, Y; Gillette, S; Fong, D; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat Biotechnol23:201-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] |
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| Synonyms: | DPDE4 | PDE32 | PDE4B | PDE4B_HUMAN | Phosphodiesterase Type 4 (PDE4B) | cAMP-specific 3,5-cyclic phosphodiesterase 4B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45579.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B. |
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| Residue: | 398 |
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| Sequence: | MGSSHHHHHHSSGLVPRGSHMSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHS
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| BDBM14795 |
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| BDBM10851 |
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| Name | BDBM14795 |
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| Synonyms: | Pyrazole carboxylic ester 18 | ethyl 3,5-dimethyl-1-(4-nitrophenyl)-1H-pyrazole-4-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15N3O4 |
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| Mol. Mass. | 289.2866 |
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| SMILES | CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)[N+]([O-])=O |
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| Structure | 
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