| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
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| Ligand | BDBM127649 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Jak2 Inhibition Assay |
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| IC50 | >1000±n/a nM |
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| Citation |  Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US9796724 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [808-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
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| Type: | Protein |
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| Mol. Mass.: | 39171.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[808-1132] |
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| Residue: | 335 |
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| Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM127649 |
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| n/a |
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| Name | BDBM127649 |
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| Synonyms: | US10251889, Example 22 | US10758542, Example 22 | US8791123, 22 | US9782415, Example 22 | US9796724, Example 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21F2N7O |
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| Mol. Mass. | 437.4452 |
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| SMILES | Cn1cc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cn1 |r| |
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| Structure | 
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