| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK3 [781-1124] |
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| Ligand | BDBM127725 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Jak3 Inhibition Assay |
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| IC50 | >1000±n/a nM |
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| Citation |  Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US9796724 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK3 [781-1124] |
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| Name: | Tyrosine-protein kinase JAK3 [781-1124] |
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| Synonyms: | JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124) |
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| Type: | n/a |
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| Mol. Mass.: | 38772.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52333[781-1124] |
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| Residue: | 344 |
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| Sequence: | ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
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| BDBM127725 |
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| n/a |
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| Name | BDBM127725 |
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| Synonyms: | US10251889, Example 98 | US10758542, Example 98 | US8791123, 98 | US9782415, Example 98 | US9796724, Example 98 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F4N6O |
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| Mol. Mass. | 434.3901 |
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| SMILES | Fc1cncc(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(CC3)C(F)(F)F)c2n1 |r| |
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| Structure | 
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